Changes in Blood Flow and Metabolism in Skin and Muscle During Induced Hyperthermia in Dogs.

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The Present study investigated the changes in blood flow and oxygen kinetics of the hindlimb skin and muscles in eighteen mongrel dogs during induced hyperthermia (38°C to 43°C). Cardiac output increased and systemic vascular resistance decreased during hyperthermia. Muscle, subdermal and dermal blood flow did not change significantly during hyperthermia. The femoral oxygen extraction rate increased significantly as the temperature was increased. The difference in lactic acid concentration between the femoral arterial and venous blood did not increase with hyperthermia. Plasma cAMP levels increased as the temperature rose, whereas cGMP levels did not increase significantly.<BR>Results of the present study suggest that the cause of hyperdynamics during hyperthermia is due to increased cAMP concentration induced by heating. Although blood flow in the muscle and skin did not increase, the oxygen supply was sufficient to maintain normal muscle metabolism during induced hyperthermia.
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