Quality of Life of Patients Treated by Radiochemotherapy Combined with Hyperthermia for Inoperable Advanced Cancer of the Thoracic Esophagus.
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概要
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The results obtained in cases inoperable advanced cancer of the thoracic esophagus were reviewed with consideration of improvement in QOL.<BR>42 patients were divided into 4 groups; 15 received hyperthermia (HT group), 8 radiochemotherapy alone (RC group), 8 bypass operation and 11 endoscopic endoprosthesis. On evaluation of local response, the response rate was 80% in the HT group and 50% in RC group with a significant differences. Five of 6 cases which could not receive oral intake before treatment showed two steps or more improvement in the HT group. Oral intake was considered impossible in only one patient. In the RC group, there was only one case which achieved 2 step improvement. Oral intake was impossible in four of 8 patients in this group. "Effective oral intake period" and "effective oral intake ratio" were calculated in terms of the length of time during which patients had effective oral digestion. An effective oral ratio of more than 90% was achieved in 5 cases in the HT group, but in only one in the RC group. Five of these six cases showed complete response to combined therapy. Therefore, it was suggested that downsizing of the tumor may lead to improvement of oral intake. The average period of staying at home were 167.3 days in the HT, 45.6 days in the RC, 0.88 days in BO, and 57.1 days in EP group. Three patients in HT and only one in RC group were allowed to remain at home for more than 90% of their survival period. The majority of patients, however, had an at home index below 30%.<BR>Radiochemotherapy combined with hyperthermia for nonresectable esophageal cancer may increase improvement of QOL in cases showing good response. Cases that showed no change or progressive disease could neither achieve improved oral intake nor liberation from hospitalization and had a poor QOL. Therefore, early management of malignant stricture after radiochemotherapy combined with hyperthermia, for example endoscopic prosthesis, is recommended in cases which show no change or progressive disease.
- 日本ハイパーサーミア学会の論文
日本ハイパーサーミア学会 | 論文
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