The timecourse of antithrombin III (AT III) level in the ischemic cerebrovascular disease
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概要
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Antithrombin III has been known a potent antithrombotic factor in a venous thrombosis. However, the role of AT III in the ischemic cerebrovascular disease has not been fully elucidated.<BR>In this study, we have investigated the time-course of AT III in 76 ischemic stroke patients with or without ad-ministration of aspirin and/or urokinase.<BR>Materials and Methods : Materials were 53 thrombotic patients (38 males and 15 females), 16 embolic patients (13 and 3), and 7 TIA patients (5 and 2). The cerebral lesion were confirmed by CT scan and cerebral angiography. AT III was measured by single immunidiffusion method (Partigen, Hoechist). The normal level of AT III was 31.3 ± 4.3 mg/dl (mean±2SD) in age-matched healthy controles (68 males and 114 females).<BR>Results : 1. The male patients under the age of 69 y.o. showed lower AT III level than that of sex-and age-matched controles (0.05<p<0.1). 2. AT III level was lower in the embolic group than the thrombotic group (0.05<p<0.1). 3. There was no significant difference of At III level among the groups which were divided by the stage of the stroke. 4. AT III level was significantly decreased in the thrombotic group either in the acute or subacute stage by the ad-ministration of urokinase (96000-46000IU/day). 5. Aspirin has significantly increased AT III level in the whole groups. This increses were marked in the lower AT III patients (AT III<27 mg/dl) and the earlier treated patients.<BR>Conclusion : These results suggested that AT III is supposed to be useful practical indicator of the blood coagulability even in the antiplatelet therapy of the ischemic stroke.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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