Studies on the parameters of blood viscosity and platelet function in patients with transient ischemic attack
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The pathogenesis of transient ischemic attack (TIA) is assumed to be closely related to that of cerebral infarction (CI) from the standpoint of clinical symptomatology, but not many studies have ever been done to evaluate the pathogenetic relationship between TIA and CI. The present study was performed to investigate the pathogenetic importance of blood viscosity and platelet function in both diseases.<BR>Several blood viscosity and platelet function parameters were measured in 20 patients with TIA at chronic stage, 15 patients with CI at chronic stage and 15 control subjects matched for age and sex.<BR>The results were as follows : <BR>1) In blood viscosity parameters, whole blood viscosity and hematocrit levels in both diseases were significantly high compared with those in controls and a positive correlation was found between whole blood viscosity and hematocrit (r=0.77, p<0.005).<BR>2) In platelet function parameters, platelet aggregability, studied with optical density methods, in both diseases was significantly great compared with that in controls, and also levels of circulating platelet aggregates and plasma factor VIII/von Willebrand factor activity in both diseases were significantly high compared with those in controls.<BR>3) In these parameters, no significant differences were found between TIA and CI.<BR>These results suggest that blood viscosity and platelet function may be some common mechanism to TIA and CI. Pathogenetic implications of these parameters were discussed in the aspect of hemorheology and blood coagulation.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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