Effect of liposome encapsulated hemoglobin on hemorrhagic shock.
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概要
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We prepared hemorrhagic shock models in dogs administered Neo Red Cell (NRC) instead of being given a blood transfusion to determine the effect of resuscitation fluid with respect to hemodynamic kinetics and oxygen kinetics. Under 50% oxygen inhalation, animals were exsanguinated at a rate of 30ml/min. Exsanguination was continued until systolic pressure decreased to 60 to 69mmHg and was followed by transfusion of NRC at the same rate. This cycle was repeated three times. First, we examined the mild shock in 6 dogs (group 1). In these experiments, NRC was transfused immediately after exsanguination. The required amount of NRC was tha same as that of the exsanguinated blood. On the other hand, we examined the more severe and irreversible shock in 7 dogs (group 2). Animals were left untreated for 30 minutes after exsanguination, then NRC was administered. NRC required 1.6 times the exsanguinated blood volume. Hemodynamically, vascular resistance decreased and the cardiac index increased in group 1 because of the low viscosity of NRC. However, vascular resistance increased gradually and the cardiandex decreased in group 2. In group 1, oxygen consumption did not increase. In group 2, oxygen consumption increased. NRC compensated for the decrease in cardiac output with an increase in the AV difference to deal with the increased oxygen consumption.
- 一般社団法人 日本救急医学会の論文
一般社団法人 日本救急医学会 | 論文
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