Residue and Toxicity of Beclotiamine in Chickens

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Becoltiamine-naphthalene disulfonate, a coccidiostat, was fed to one-day-old White Leghorn male chickens for 8 weeks in doses of 125ppm, 500ppm, and 1000ppm in the diet. As controls, non-medicated diet or diets containing thiamine -NDS at 125ppm and 1000ppm were fed to the chickens.Quantities equivalent to about 0.4ppm and 0.04ppm and beclotiamine-HCl were detected in liver and muscle, respectively, of the birds fed at the dose of 125ppm in the diet. When the dose of beclotiamine was increased to four to eight times greater, no accumulation of the coccidiosatat occurred in the tissues throughout the entire 56 days of the medication. Beclotiamine rapidly disappeared from the tissues once the compound was withdrawn from the diet. Neither growth depression nor decrease in thiamine levels in the liver occurred by administration of beclotiamine.Weights of liver, heart, brain, spleen, adrenal gland, kidney, and testis were not influenced by administration of beclotiamine or thiamine.Serum acid phosphatase, alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activities and serum protein, cholesterol, and serum glucose were all within the normal range. No histophathological changes were observed in the liver.
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