Antitumor effect of recombinant human interleukin 1 alpha against murine syngeneic tumors.
スポンサーリンク
概要
- 論文の詳細を見る
Interleukin 1 (IL1) has been suggested to have antitumor activity but there is no clear-cut evidence of an in vivo antitumor effect of pure IL1. In this work, the antitumor effect of purified recombinant human IL1 alpha (rHu-IL1α) was assessed on murine tumors transplanted intradermally in syngeneic female mice. rHu-IL1α inhibited the growth of Meth A sarcoma in BALB/c mice, B16 melanoma in C57BL/6 mice and colon 26 adenocarcinoma in CDF1 mice, as well as the spontaneous pulmonary metastasis of Lewis lung carcinoma in BDF1 mice, at intratumoral (itu), intramuscular (im), and/or intravenous (iv) doses ranging from 1 to 30μg/mouse. The antitumor effect of rHu-IL1α was generally dose- and route-dependent, being highest by the itu route, followed by the im and iv routes in that order. Palpable 7-day-old Meth A sarcoma was completely regressed in some mice given rHu-IL1α itu once at doses of 10-30μg/mouse (cured ratio; 71-100%), once a day for 3 days at doses of 3-30μg/mouse (57-86%) or once a day for 7 days at doses of 1-10μg/mouse (14-100%). Palpable 7-day-old B16 melanoma was also regressed completely in some mice given seven itu doses of 10-30μg/mouse (14-86%). One-day-old Meth A sarcoma was more sensitive to rHu-IL1α than 7-day-old Meth A sarcoma. There was no macroscopic sign of inflammation at the site of injection of rHu-IL1α. These results show that rHu-IL1α has antitumor activity in vivo and is worthy of further study as a potential antitumor agent.
- 日本癌学会の論文
日本癌学会 | 論文
- Suppressive Effect of Prednisolone on Cytotoxicity of Lymphocytes from Normal Persons Against T24 Cells
- Organotropic Effect of N-Bis(2-hydroxypropyl)nitrosamine--Production of Lung and Liver Tumors by Its Oral Administration in Mice
- Effect of Dose on the Carcinogenic Activity of Orally Administered N-BIS(2-Hydroxypropyl)Nitrosamine in Rats
- Carcinogenic Activity of 3-Di(hydroxymethyl)amino-6-(5-nitro-2-furyletheny1)-1,2,4-triazine(panfuran-S)in Male Rats(Communication)
- Enhancement of pancreatic tumorigenesis of 4-hydroxyaminoquinoline 1-oxide by ethionine in rats (Note)