High level of .BETA.-type transforming growth factor activity in human urine obtained from cancer patients.
スポンサーリンク
概要
- 論文の詳細を見る
Activity of transforming growth factor (TGF) in urine was examined by the use of cloned BALB/3T3 A31-1-1 indicator cells. When urine was extracted by an acid-ethanol method, fractionated on a Bio-Gel P-100 column, and analyzed for TGF activity, samples from healthy persons showed no activity, but 80% of the samples from advanced cancer patients had the activity. Activity observed in tumor-bearing patients was eliminated after therapy. Further analysis was carried out in a much simpler way by the fractionation of urine samples after only dialysis and lyophilization. An extensive survey of TGF activity in urine using BALB/3T3 indicator cells revealed weak or intermediate (19%) activity in healthy persons and high (56%) or intermediate (31%) activity in advanced cancer patients. When urine samples were analyzed and compared using both BALB/3T3 cells and NRK 49F cells, the BALB/3T3 cells were shown to form colonies in response to β-type TGF but not to α-type TGF. The present results are the first demonstration of an elevated level of β-type TGF in urine from cancer patients.
- 日本癌学会の論文
日本癌学会 | 論文
- Suppressive Effect of Prednisolone on Cytotoxicity of Lymphocytes from Normal Persons Against T24 Cells
- Organotropic Effect of N-Bis(2-hydroxypropyl)nitrosamine--Production of Lung and Liver Tumors by Its Oral Administration in Mice
- Effect of Dose on the Carcinogenic Activity of Orally Administered N-BIS(2-Hydroxypropyl)Nitrosamine in Rats
- Carcinogenic Activity of 3-Di(hydroxymethyl)amino-6-(5-nitro-2-furyletheny1)-1,2,4-triazine(panfuran-S)in Male Rats(Communication)
- Enhancement of pancreatic tumorigenesis of 4-hydroxyaminoquinoline 1-oxide by ethionine in rats (Note)