Potentiation by squalene of antitumor effect of 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-nitrosourea in a murine tumor system.
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The effect of squalene (SQ) on the antitumor activity of 3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea (ACNU) was studied in a murine tumor system. SQ at 4.2g/kg exhibited a significant potentiating effect on the activity of 10mg/kg of ACNU against lymphocytic leukemia P388 and resulted in some long-term survivors without toxicity to the host. Simultaneous administration of SQ and ACNU was most effective.
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