A protein cross-reacting immunohistochemically with rat glutathione S-transferase placental form as a marker for preneoplasia in syrian hamster pancreatic and hepatocarcinogenesis.
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概要
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Immunohistochemical staining using antirat glutathione S-transferase placental form (GST-P) rabbit antibody demonstrated marked binding to cells of putative preneoplastic lesions induced in both the liver and pancreas of Syrian hamsters by dihydroxy-di-n-propylnitrosamine treatment, whereas background normal-appearing tissue was negative. Thus, a protein showing immunological cross-reaction with rat GST-P is also elevated during pancreatic carcinogenesis and hepatocarcinogenesis in the hamster, suggesting its usefulness as a marker with potential relevance to the mechanisms underlying the neoplastic process.
- 日本癌学会の論文
日本癌学会 | 論文
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