EFFECTS OF X-RAY IRRADIATION UPON METABOLISM OF DESOXYRIBONUCLEIC ACID AND DESOXYRIBONUCLEASE. II. IN RAT TUMOR
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1) The metabolism of DNA of rat tumor, and liver and spleen of the tumor bearing animals were studied with the use of 32P, the charcteristic time course of the specific activity of the DNA, prepared by the method of Mirsky and Pollister and purified by Wyatt′s procedure, was observed in each of the tissues.2) The DNase II activity was measured by the method of Allfrey and Mirsky, and a close correlation of the DNase II activity was observed with the metabolic rates of DNA of each tissue by the use of 32P, namely highest in tumor, and low activity in liver.3) Following whole body X-ray irradiation, the metabolic rates of DNA of each tissue was depressed conciderably, and on the contrary, the DNase II activity was enhanced after irradiation, namely the DNase II activity of the spleen was increased about two fold.4) On the mechanism of augmentation of DNase II activity caused by the X-ray irradiation some in vitro experiments were carried out, paticulary from the standpoint of the enzyme protein synthesis.
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