DISTRIBUTION OF RADIOACTIVE IRON INJECTED INTO TUMOR-BEARING ANIMALS
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Radioactive iron was injected into control and tumor-bearing rats. The tumor used was Rhodamine sarcoma, which is relatively free from necrosis and hemorrrhage. The iron amount and radioactivity were determined in tumor, plasma, hemoglobin, liver, kidney and spleen 24 hours after the injection.The concentration of iron in liver and plasma decreased in tumor-bearing animals. The incorporation of radioactive iron into hemoglobin increased and the incorporation of radioactive iron into liver decreased in tumor-bearing animals. It was estimated that the total iron contained in tumor-tissue was larger than the total iron amount in liver.Distribution of iron in tumor-bearing animals was discussed in relation to anemia, liver catalase depression and porphyrin acummulation in liver and red cells in the case of tumor-bearing animals.
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