INHIBITORY EFFECT OF THE HIGH MILIEU UPON THE DEVELOPMENT OF THE EXPERIMENTAL LIVER CANCER
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概要
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Purporting to settle experimentally the problem of carcinogenesis in connection with the life milieu, especially the natural milieu, p-dimethylaminoazobenzene was administered to rat up to 450mg per head in average, 4 to 5 months long and in groups where one group was maintained at the altitude of about 2800m and atmospheric pressure of 549.4mm Hg and the other group on a low terrain. The results are summarized as follows:1) Tumor incidence of the test animal gave 44.4per cent with the high level group against 62.5per cent with the low level group toward the 120th experimental days and 55.5per cent with the former against 92.9 per cent with the latter toward the 150th experimental day. This denotes that carcinogenesis in the liver caused through DAB suffers inhibition in the high altitude than in the lower level. Histological features of the liver cancer somewhat differ from each other according to the living altitude.2) Hepatic changes of benign nature and of DAB origin projected a vertical difference to two level groups against each time extent of 4 to 5 months. In the high level group, the affected area was rich in nodular cirrhosis with a distinct annular texture but poor in cholangiofibrosis; on the contrary, in the low level group, the annular structure was less pronounced among cirrhotic area against well developed cholangiofibrosis accompanied by inflammatory cell infiltration. Besides, a variety of degeneration of nodular hyperplasia cells is encountered more in high than in low level samples through 4 to 5 months, and a peculiar liver necrosis was noticed in the high level samples at the 4th month (which seemed effaced with disuse of DAB).3) Comparing the histological findings of hormonal organs each at the 4th and 5th month, there was established degenerative atrophy of the cells of anterior lobe of pituitary and adrenal cortex in the high level group and some hypertrophy plus hyperplasia of the cells of these organs in the low level group. Certain consideration was paid on the correlation between carcinogenesis and the functional changes of these hormonal organs.4) There were established also erythropoiesis cum leucopenia in the high level group and leucopoiesis in the low level group.
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