PREPARATION OF POTENT CONCENTRATES OF TOXOHORMONE FREE FROM NUCLEIC ACID
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A fraction was obtained from acetone dry powder of rhodamine sarcoma, transplantable rat hepatome and NF-sarcoma with hot acetic acid-methanol (2:3), extraction. That from rhodamine sarcoma was effective in 20mg injecting doses for mouse in depressing liver catalase activity and in reducing thymus weight, and those from hepatoma and NF-sarcoma were effective in 40mg doses for both actions.One sample of the fraction derived from rhodamine sarcoma was subjected to ethyl alcohol fractionation, and divided into 4 fractions. The activity for thymus involution was distributed almost equally among them, but catalase depressing action was demonstrated only in fraction No. 3, which was active in 10mg dose. The procedure of acid-methanol extraction was applied to raw toxohormone, and yielded a fraction effective in 10mg doses for liver catalase depression, with no toxicity for mouse.No nucleic acid contents were detected in any of these fractions by means of phosphate determination and ultraviolet absorption test.Our hearty thanks are due to Dr. Nakahara for his kind interest and encouragement.
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