Prognostic significance of the proliferative activity of human hepatocellular carcinoma shown by bromodeoxyuridine uptake
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To determine the significance of the proliferative activity of hepatocellular carcinoma (HCC), we studied the bromodeoxyuridine (BrdU) labeling index (L. I.) in 24 consecutive patients with HCC. The BrdU L. I. ranged from 0 to 17.8%, averaging 3.01±4.22% (mean ± SD). Conventional pathological features of HCC such as tumor size, intrahepatic metastasis, vascular involvement, were not correlated with the BrdU L. I. Multivariate analysis revealed that the BrdU L. I. was a significant predictor of the disease-free survival time.Both the disease-free survival time and the survival rate of the low BrdU L. I. (>2%; n=12) group were significantly better than those of the high BrdU L. I. (>2%; n=7) group (p=0.0275 and 0.0462, respectively). All patients in the high BrdU L. I. group showed recurrence within 2.5 years compared with only 40% of the low BrdU group. In conclusion, measurement of the BrdU L. I. is a useful tool for the follow-up of HCC patients.
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