Biochemical Studies on Serum in Obesity:Report 8. Studies on Serum Protein and Compound Protein
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Abnormalities of metabolism centering around lipids in obesity were studied from the viewpoint of serum protein and compound proteins. At the same time these were studied from the chemical feature of serum for the purpose of establishing a relation with vascular sclerosis, hypertension and diabetes which are closed related to obesity.In 22 patients with obesity, electrophoretically-separated protein fractions were measured; cholesterol was ascertained in relation with lipoprotein; the total protein-combining carbohydrate was determined in connection with glycoprotein.The patients were treated with Neo-bazett which was mainly made up of dinitrophenol, and its effects were explored principally from the angle of serum features.1. Serological findings in obesity were a decrease in the albumin fraction, a decrease in the albumin/globulin ratio and an increase in the α-and γ-globulin fractions.A decrease in the β-lipoprotein fraction took place in many cases. The γ-lipoprotein fraction showed a slight increase. On the other hand, there was an evident increase in the total cholesterol level. The same tendency was observed in the esterified cholesterol level, and the ester ratio was nearly normal.As for glycoprotein, an increase in the fraction was prominent, and the total protein-combining carbohydrate level had an increasing tendency.2. These serological findings were not improved even when treatment of the patients with Neobazett brought about a decrease in body weight.3. From these biochemical features of serum, the relationship was observed between obesity and diabetes or vascular sclerosis.
- 日本電気泳動学会の論文
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