Proteomics for hepatocellular carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Chronic infection with hepatitis C virus (HCV) is one of the most clearly established risk factors for hepatocellular carcinoma (HCC). The number of HCV-carriers in Japan is estimated to be 2 million and 32, 000 of HCC patients pass away every year. Therefore, it is important to clarify the mechanism involved in hepatocarcinogenesis by chronic HCV infection.We performed proteomic studies using samples of tumor tissues and non-tumor tissues from HCC patients with HCV infection but not hepatitis B virus infection. This study using two-dimensional gel electrophoresis with MALDI-TOF-MS showed that HSP70 family such as GRP78, HSC70, GRP75 and HSP70.1, glutamime synthetase isoforms, alpha-enolase, phosphoglycerate mutase, and triosephosphate isomerase were increased but albumin, ferritin light chain, smoothelin, tropomyosin beta chain, arginase 1, aldolase B and ketohexokinase were decreased in the tumor tissues.
- 日本電気泳動学会の論文
日本電気泳動学会 | 論文
- Multiple reaction monitoring をバリデーションに用いた質量分析による血漿バイオマーカー探索システムの検討
- リポソームをリガンドとして用いた血漿蛋白質のプロテオミクス解析
- 白血球DNAの分析と症例
- キャピラリー電気泳動およびDHPLCによる遺伝子解析法
- 骨髄由来細胞動員を介した組織再生制御機構