Effects of quercetin on the growth of JURKAT cells and the phosphorylation of MAP kinase families.
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概要
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Effects of quercetin on the growth of JURKAT cells and the phosphorylation of MAP kinase families were examined. Quercetin inhibited the growth of JURKAT cells and induced DNA fragmentation. Quercetin enhanced the phosphorylation of ERK at 24h, and then inhibited at 48-96h. The phosphorylation of JNK was not affected by quercetin. The phosphorylation of p 38 MAPK was inhibited at 48-96h by quercetin. Thus, modulation of the phosphorylation state of MAP kinase families might be implicated in the quercetin action on the growth of JURKAT cells.
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