Prospective advancement in bioinformatics generated by unification of genome database and proteome database.
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概要
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After completion of the Human Genome Project, the main target of the next research has shifted to elucidation of functions of unidentified novel genes. In this situation, expectation for the contribution of proteomic research to the bioinformatics has been getting heavier. The unification of genome database and proteome database may promote an advancement of post-genome researches. All spots of proteins isolated on a 2-D gel pattern can be easily assigned to their own sequence on a chromosome by tblastn search served by NCBI. After the mapping of all 2-D gel spot to genomic DNA, the function of unidentified genes will be thoroughly inquired by proteomic research. Many techniques in proteomics can offer much information about tissue/cell specific expression of the gene products, functional regulation by differentiation and carcinogenesis, intracellular localization, protein-to-protein interaction, and posttranslational modifications. A lot of information gathered by proteomic research may help us to assign a specific function to each protein corresponding to its unidentified gene.
- 日本電気泳動学会の論文
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