Regulatory mechanisms of proliferation, differentiation and morphogenesis of stomach epithelia.

概要

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Stomach epithelia proliferate and differentiate continuously throughout life, playing various organ-specific roles. The regulatory mechanisms of proliferation and differentiation of the epithelia is under the control of a genetic program called epithelial-mesenchymal interaction. Some of the factors that mediate the interaction have recently been identified: there is a great deal of evidence that the components of extracellular matrix control the morphology and function of epithelial cells in various organs. Moreover, some soluble mesenchymal factors turns out to be mitogen, motogen and morphogen for various epithelial and endothelial cells. The results of our recent studies, both in vivo and in vitro, also demonstrate that the proliferation and differentiation of gastrointestinal epithelial cells is regulated region-specifically not only by soluble factors but also by insoluble components of the ECM. With various other factors such as systemic hormones, gastrointestinal polypeptides, neuronal factors and acidic environment of the gastric lumen playing as active modulators, the epithelial-mesenchymal interaction is deeply involved in the development and maintenance of morphology and functions of the stomach.
日本電気泳動学会の論文