Biochemical properties of macro creatine kinase type 1 and type 2.
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概要
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The biochemical properties of macro creatine kinase type 1 found in seven patients and type 2 found in one case were examined. In the cases of macro creatine kinase type 1, three patients with creatine kinase BB linked immunoglobulin G and three patients with creatine kinase MM linked immunoglobulin A were determined. Two forms of macro creatine kinase were easily differentiated by the determination of their distinct activation energies. Molecular masses of macro creatine kinase type 1 were approximately estimated to be from 230, 000 to 330, 000, and multi-molecular forms of macro creatine kinase type 2 were observed by the method of gel permeation high performance liguid chromatography. Two forms of macro creatine kinase were mainly detected in patients with malignancies.
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