Research on shifts in lactate dehydrogenase isozymes in mouse tissues during development.
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概要
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Lactate dehydrogenase† (LDH) activity and LDH isozyme in seven tissues of ddn strain mice during development from the embryo to the adult were investigated. The following results were obtained: (1) Comparison of the LDH activities in the various tissues on the 19th day of gestation and the 7th day after birth showed that the activities in the kidneys, liver and skeletal muscle increased, while, those in the cerebrum, cerebellum, heart and lungs decreased on the 7th day after birth. (2) The main isozyme activity on the 7th day after birth shifted to LDH-4 in the cerebrum and to LDH-3 in the cerebellum and heart. (3) Tissue specific isozyme pattern was seen in the cerebrum on the 56th day after birth and the isozyme activities were in the following order: LDH-3>LDH-1>LDH-4>LDH-2…. In the cerebellum, the pattern was seen on the 21st day after birth with a gradual decrease of isozyme activity from LDH-1 to LDH-5. In the lungs, the isozyme activities were LDH-5>LDH-4… from the 12th day of gestation and even after birth.
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