Midazolam as a Sedative during Spinal Anesthesia.

概要

論文の詳細を見る
The hemodynamic and respiratory effects of the intravenous sedative midazolam at different doses were studied in 61 patients undergoing simple hysterectomy under spinal anesthesia. Eighteen patients received midazolam at the dose of 0.05mg/kg, 23 received 0.1mg/kg, and 20 received 0.05mg/kg as well as 2.5mg droperidol as prophylaxis against the nausea which sometimes occurs during intraabdominal procedures. Satisfactory sedation was provided by midazolam at either 0.1 or 0.05mg/kg with or without droperidol, and hemodynamic changes caused by midazolam were minimal and within acceptable limits. On the other hand, there was significant reduction in both tidal volume and arterial oxygen saturation monitored with pulse oximeter (SpO2) at all dosages. Administration of 0.1mg/kg midazolam was associated with greater degree of upper airway obstruction and more marked reduction in SpO2 than was that of 0.05mg/ kg. In droperidol-treated patients, nausea was noted less often but hypotension was observed more frequently than in patients given midazolam only. It is concluded that midazolam at the dose of 0.05mg/kg provides adequate sedation and is suitable for sedation during spinal anesthesia. However, after administration of even a small dose of midazolam, marked reduction of SpO2 may ensue.
日本臨床麻酔学会の論文