Depletion of Thymic Macrophages in the Rat by Liposome-Encapsulated Dichloromethylene Diphosphonate.
スポンサーリンク
概要
- 論文の詳細を見る
Liposome-entrapped dichloromethylene diphosphonate (Cl2MDP) was injected locally into the thymus of adult rats. This treatment, which has been found to deplete resident macrophages in other organs, also reduced the number of thymic macrophages. The depletion was evident in the cortex and the corticomedullary zone at 5, 13 and 23 days after Cl2MDP treatment, while the decrease in medullary macrophages only became significant 13 and 23 days after injection. However, the maximal reduction of macrophages was evident 13 days after this treatment. Thirty-five days after Cl2MDP treatment, macrophages repopulated the thymus. Our results suggest that the cortical and cortico-medullary macrophages have a high phagocytic activity consistent with their predominant role as scavengers of the large numbers of thymocytes that die under physiological conditions. It is concluded that liposome-mediated depletion of thymic macrophages can serve as an experimental model to study the roles of these cells.
- 国際組織細胞学会の論文
国際組織細胞学会 | 論文
- Immunohistochemical localization of vascular endothelial growth factor in the endocrine glands of the rat
- Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer’s disease brains
- A longitudinal study on the expression of the opsin gene in the degenerating retina of C3H/He mice.
- Expression of the arylhydrocarbon receptor in the periimplantation period of the mouse uterus and the impact of dioxin on mouse implantation
- Immunohistochemical studies on the development of tyrosine hydroxylase- and serotonin-immunoreactive neurons in fetal dorsal raphe tissue transplanted into the anterior eye chamber of adult rats.