A Muscle Biopsy Study on Skeletal Muscle of Elderly Patients.
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概要
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The purpose of this study was to obtain the histological and histochemical findings regarding skeletal muscle of elderly patients. The subjects were I male and 9 female patients with fracture of the neck of the femur, aged 80-90 years, who had received operations at the Ohashi Hospital of Toho University. Muscle biopsies were taken from the vastus lateralis muscle by the open biopsy technique. Serial transverse frozen sections (10 μm thick) were cut on a cryotome at -20°C. The myofibrillar ATPase method was used for muscle fiber classification into slow twitch (type 1) and fast twitch (type 2) fibers. The reactions were carried out at pH 9.4 followed by alkaline preincubation (pH 10.3). Various changes observed in skeletal muscles and the results were summarized as follows: 1) Atrophy of type 2 fiber was seen in all patients, and that of type I fibers (postural slow fibers) was smaller compared with type 2 fibers. 2) Neuropathic changes: Small angulated fibers were seen in 5 of 10 patients. Small group atrophy and type 2 fiber predominance were present in 3 of 10 patients. 3) Myopathic changes: Variation in muscle fiber size was seen in 3 of 10 patients. Interstitial fibrosis was also observed in 3 patients, and opaque fibers and cetnral nucleis were seen in I patient each. In the present findings, myopathic as well as neuropathic changes were observed in skeletal muscles of elderly patients, and neuropathic changes were more prominent. The patients with neither neuropathic nor myophathic changes exhibited good prognosis of gait ability.
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