Appearance of Platelet-Clumping Substance in Plasma from Humans with Thrombosis, Infection or Tissue Destruction

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The platelet-clumping substance in plasma collected from 200 hospitalized patients which included 34 healthy volunteers, was examined. The platelet-clumping substance was present in 4 out of 34 heparinized plasmas collected from healthy volunteers. It was markedly present in cases with an acute stage of thrombosis, bacterial infections, common colds, rheumatoid arthritis and malignant tumors (p<0.01). The platelet count in the cases of acute thrombosis and bacterial infections decreased significantly (p<0.05). In other miscellaneous diseases the appearance of the platelet-clumping substance and the decrease in the platelet count was not significant. The platelet-clumping substance was not detectable in serum and citrated, oxalated or EDTA-plasma, but the substance in heparinized plasma did not disappear after the addition of citrate, oxalate or EDTA to the plasma. It was stable for the storage at 4°C and was not dialyzable. These results suggest that the platelet-clumping substance in human plasma is similar to that previously detected in rabbit plasma and that it differs from ADP, thrombin, adrenaline and plasma cofactors of ADP.
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