Effects of chlorinated aliphatic hydrocarbons on mitochondrial oxidative phosphorylation in the rat with reference to the effects of chlorinated aromatic hydrocarbons.

概要

論文の詳細を見る
The effects of chlorinated aliphatic hydrocarbons on mitochondrial energy transfer reactions in the rat were examined. Of the chlorinated aliphatic hydrocarbons examined, tetrachlorinated ones inhibited the respiratory control more strongly than trichlorinated ones with increasing state 4 respiration. The effect of chlorinated aliphatic hydrocarbons on the respiratory ccntrol was in the order of tetrachloroethylene > 1, 1, 1, 2-tetrachloroethane > trichloroethylene > 1, 1, 1-trichloro-ethane. These results indicate that chlorinated aliphatic hydrocarbons act as un-couplers of mitochondrial oxidative phosphorylation. The difference between the effects of chlorinated aliphatic and chlorinated aromatic hydrocarbons on the energy transfer reactions of rat liver mitochondria is discussed.
独立行政法人労働安全衛生総合研究所の論文