AN EXPERIMENTAL STUDY ON TERATOGENIC EFFECT OF CADMIUM

概要

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Administration of 5 mg per kilogram of cadmium chloride to pregnant mice on 7 days of gestation produced a variety of malformations in the surviving fetuses. Exencephaly was found most among the fetuses and such exencephalic fetuses also often exhibited open eye. Clefts palate and lack of tail or rachischisis were also found in some other fetuses. Skeletal malformations were observed in the skull region, vertebral parts, ribs and tails. The total rate of malformation appearance exceeded about 80%. The less the dosis of cadmium chloride, the less the rate of malformation appear-ance: 19% for 2.5 mg/kg 1.0% or less for 0.63 mg/kg and none for 0.33 mg/kg. The quantities of cadmium in the liver, the kidneys and the placentas of the mother animals and fetuses were measured by atomic absorption spectrophotometry. The cadmium content in the liver of cadmium chloride injected mother animal was 800 times greater than the control animal, that in the kidneys was 450 times and that in the placenta 10 times, but measurable amount of cadmium was not de-tected among fetuses of cadmium chloride injected mice. Above mentioned fact expresses that cadmium chloride in the late pregnancy does not transfer through the placenta and stays in the mother's side.
独立行政法人労働安全衛生総合研究所の論文