Fibrinopeptides A and B of baboons (Papio anubis, Papio hamadryas, and Theropithecus gelada): Their amino acid sequences and evolutionary rates and a molecular phylogeny for the baboons.

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Amino acid sequences of fibrinopeptides A and B from savanna baboons, Papio anubis and Papio hamadryas, and highland baboon, Theropithecus gelada, were established. The sequences of the fibrinopeptides A from the three baboons were identical: Ala-A_??_p-Thr-Gly-Glu-Gly-A_??_p-Phe-Leu-Ala-Glu-G_??_y-Gly-Gly-Val-A_??_g. The fibrinopeptides B were composed of 9 residues and demonstrated the sequence: Asn-Gln-Glu-Gly-L_??_u-Phe-_??_-Gly-A_??_g, where_??_=Arg in P. anubis, His in P. hamadryas, and Gly in Th. gelada. Position-3 of the B peptides was the only replacement site observed among the 25 amino acid residues in both fibrinopeptides from the baboons. Based on these sequences, a molecular phylogeny for the three species of baboons was deduced. The evolutionary rates of the peptides B of the baboons and macaques were also estimated. It was observed that the fibrinopeptides changed at an uneven rate during the evolution of old-world monkeys, i.e., baboons and macaques.
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