The asparagine-linked sugar chains of plasma membrane glycoproteins of K-562 human leukaemic cells: A comparative study with human erythrocytes.
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The paper electrophoretic pattern of the oligosaccharides released from the plasma membranes of K-562 cells by hydrazinolysis was quite different from that of human erythrocyte membranes. Bio-Gel P-4 column chromatography in combination with sequential exoglycosidase digestion of the neutral oligosaccharide fractions revealed that all those from K-562 cells are of the high mannose type, while those from erythrocytes are of large complex type structures. Studies of the acidic oligosaccharides indicated that none of those obtained from K-562 cells contained the β-N-acetylglucosamine residue linked at the C-4 position of the β-mannosyl residue of the trimannosyl core, which occurs in most of the asparagine-linked sugar chains of human erythrocytes. This indicates that the glucosaminyltransferase that forms the GlcNAcβ→4 Manfβ1→4 group has not been expressed in K-562 cells.
- 社団法人 日本生化学会の論文
社団法人 日本生化学会 | 論文
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