Antibody against the C-terminal portion of dystrophin crossreacts with the 400kDa protein in the pia mater of dystrophin-deficient mdx mouse brain.
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The mdx mouse is an animal model for X-linked Duchenne muscular dystrophy. A polyclonal antibody against a synthetic peptide IV equivalent to the C-terminal portion (amino acids 3495 3544) of dystrophin crossreacted with a 400kDa protein in the brain and the spinal cord of mdx mouse, as well as in the control B10 mouse. However, the protein did not crossreact with the polyclonal antibody raised against the N-terminal portion of dystrophin peptide I (amino acids 215-264). Immunofluorescent micrography revealed that the outside of the small arteries and the pia mater of the brain strongly reacted with the anti-peptide IV antibody. These results strongly suggest the presence of a crossreactive protein other than dystrophin, possibly a dystrophin-related autosomal gene product, in the pia mater.
- 社団法人 日本生化学会の論文
社団法人 日本生化学会 | 論文
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