Ascertainment of IgA1(.KAPPA.)-Transferrin Complex in a Case of Multiple Myeloma Associated with Hypersiderinemia.
スポンサーリンク
概要
- 論文の詳細を見る
IgA1(κ)-transferrin complex was ascertained in a case of multiple myeloma with hypersiderinemia. On gel filtration, this complex disclosed an orange-colored protein with two peaks between the 19S and 7S fractions. On polyacrylamide gel electrophoresis and Western blotting analysis, the complex migrated at molecular weights of 430 and 700 kD in the non-reducing condition. A small amount of free transferrin was detected simultaneously. The complex was further separated into monoclonal IgA1(κ) and transferrin at pH 4.5; these recombined at pH 7.2 after incubation (37°C, 2 h). We also showed that the pepsin-digested F(ab')2 fragment of IgA1(κ) combined with the transferrin. From these results it can be suggested that monoclonal IgA1(κ) has an antibody activity for the transferrin. Clinically, this complex disturbed the iron transport to erythroid cells in the bone marrow, resulting in hypersiderinemia, anemia, and iron deposits in the liver.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
- Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia
- 脳腱黄色腫に微小変化型ネフローゼ症候群を合併した1例
- Brugada Syndrome Case: Difficult Differentiation Between a Concealed Form and Tricyclic Antidepressant-induced Brugada Sign
- Brugada Syndrome Whose ST-segment Changes were Enhanced by Antihistamines and Antiallergenic Drugs
- Edaravone Diminishes Free Radicals from Circulating Neutrophils in Patients with Ischemic Brain Attack