The In Vitro Effect of Vincristine on the Blast Cell Renewal in Acute Myeloblastic Leukemia.
スポンサーリンク
概要
- 論文の詳細を見る
The goal of chemotherapy for acute myeloblastic leukemia (AML) may only be achieved by eradicating the self-renewal capacity of the blast progenitors. In this regard, chemotherapeutic drugs should be screened according to their effects against self-renewal. The present report was aimed to study the effect of the vinca alkaloid, vincristine (VCR), on the terminal divisions and self-renewal of the blast progenitors. A primary colony assay was utilized to reflect the former and a secondary colony assay and suspension culture to reflect the latter in AML patients. The results indicated that in many of the cases studied, VCR was considered to be almost equally toxic to terminal divisions and self-renewal of the blast progenitors. An almost equivalent cytotoxicity of VCR was also noted against normal hematopoietic cells, assessed by colony-forming unit granulocyte-macrophage (CFU-GM) assay. This study suggested that successful chemotherapy with VCR may be more easily achieved in combination with other drugs that are highly inhibitory to the self-renewal of the blast progenitors.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
- Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia
- 脳腱黄色腫に微小変化型ネフローゼ症候群を合併した1例
- Brugada Syndrome Case: Difficult Differentiation Between a Concealed Form and Tricyclic Antidepressant-induced Brugada Sign
- Brugada Syndrome Whose ST-segment Changes were Enhanced by Antihistamines and Antiallergenic Drugs
- Edaravone Diminishes Free Radicals from Circulating Neutrophils in Patients with Ischemic Brain Attack