Human Trophoblastic Cells Metabolize 25-Hydroxyvitamin D3 In Vitro.
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概要
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Human trophoblastic cells (T3M-3) metabolized 25-hydroxyvitamin D3 into two more polar metabolites during in vitro incubations. A two-step high pressure liquid chromatography system revealed two unique elution positions of those trophoblastic cell-derived metabolites that exactly co-migrated with the elution positions of 5(Z)-19-nor-10-oxo-25-hydroxyvitamin D3 and 5(E)-19-nor-10-oxo-25-hydroxyvitamin D3, respectively. These unique metabolites did not bind specifically to a protein receptor for 1, 25-dihydroxyvitamin D3.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
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