Bile duct lesions and diminution in number of intrahepatic bile ducts in asymptomatic primary biliary cirrhosis.
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概要
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Morphological changes of interlobular bile ducts in asymptomatic or symptomatic primary biliary cirrhosis (PBC) and chronic hepatitis with ductal lesions were investigated. It was supposed that bile duct lesions found in PBC and chronic hepatitis could be distinguished histologically. There were identical epithelial changes between symptomatic PBC and asymptomatic one, but granulomas were more often found in asymptomatic PBC than in symptomatic PBC. Numbers of interlobular bile ducts per portal tract and the rates of portal tracts without interlobular duct in asymptomatic PBC were intermediate between symptomatic PBC and chronic hepatitis. Serial sections revealed that somebile ducts were able to be followed by ductules in asymptomatic PBC. From these results, numbers of interlobular bile ducts are undoubtedlydecreased in asymptomaticPBCbut not so muchas in symptomaticone. This observation maybe attributable partially for taking asymptomatic course.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
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