The changes in plasma lipoproteins in a case of heterozygous familial hypercholesterolemia after plasmapheresis.
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The changes in plasma lipoproteins after plasmapheresis were estimated in a case of heterozygous familial hypercholesterolemia. Twoand a half liters of plasma were exchanged with the same volume of Plasmanate. The effects of cholestyramine on the changes in plasma lipoproteins were also studied after the second plasmapheresis. Fasting plasma was collected serially, and plasma VLDL, IDL, LDL1 (1.019<d<1.045), LDL2 (1.045<d<1.063), HDL2 (1.063<d<1.125)and HDL3 (d>1.125) were separated by ultracentrifugation. The cholesterol and apoprotein contents in these lipoprotein fractions were analyzed. Apoprotein AI, AH, B, CII and E were measured by single radial immunodiffusion. VLDLC and plasma apoprotein CII and E increased very rapidly. The IDL-C increase was slightly slower than that of VLDL-C.LDL1-C continued to increase for three weeks, but LDL2-C reached a plateau around a week after plasmpheresis and declined thereafter. The change of apoprotein B was similar to that of cholesterol in VLDL, IDL, LDLi and LDL2. Cholesterol amounts in HDL2 and HDL3 changed in a parallel manner, as did apoprotein AI and AIL HDL2 and HDL3 reached their preplasmapheresis levels in a week. Cholestyramine did not inhibit the increase of VLDL, IDL, LDL1 or LDL2 in this case.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
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