Neuraminidase activity in human peripheral lymphocytes Its increase in chronic active liver disease.
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The activity of neuraminidase (sialidase) in peripheral white blood cells was measured by a fluorometric method using 4-MUNANAas a substrate. The activity in mononuclear cells, which was predominantly lymphocytes, was 2.5 times higher than that in polymorphonuclear cells (neutrophils). The former's activity was directly proportional to the numberof the cells, but that of the latter was found to be suppressed by an increasing number of cells. Thus, the increased number of PMNcontaminated in MNC fraction somewhat obscured neuraminidase activity affecting suppressively. The enzyme activity in MNC of 25 control subjects (15 males and 10 females) was 254±73 pmoles per hour per 106 cells and there was no difference between the values in males and females (233±59 vs. 284±81). The activity in 20 patients with chronic active liver disease was significantly higher than that in controls (551±135, p<0.01). The amount of sialic acid in MNC, which was 1.4 times more than that in PMN, revealed a tendency for a positive correlation between neuraminidase activity. A new finding of the increase of lymphocyte neuraminidase activity was inroduced and its pathological significance particularly in liver disease was discussed.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
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