Effect of dexamethasone on tne growth of human lymphoblastoid cell lines.
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概要
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Effect of dexamethasone od the growth of two T-cell acute lymphoblastic leukemia (TALL) cell lines, JM and TALL-1 and an American Burkitt lymphoma cell line, Ramos, ofB-cell type was examined. While the growth of both TALL-1 and Ramos cell lines wassignificantly inhibited by dexamethasone at the low concentration of 10-7M, JM cell linewas markedly resistant at the high concentration of 10-5M of dexamethasone. The assayof glucocorticoid receptors showed that a small amount of the binding site was found inboth T-cell leukemia cell lines, JM and TALL-1 and that a moderate amount of the binding site was found in Ramos cell line. Thus, glucocorticoid sensitivity (growth inhibition of these leukemia-lymphoma cell lines by dexamethasone) did not correlate with either the number of glucocorticoid receptor or with surface membrane markers of the target cells.This result suggests further marked heterogeneity of leukemic cells.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
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