Effects of Osmolarity and Echinocytogenic Drugs on the Transport of Phosphoenolpyruvate through the Red Cell Membrane

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The transport of phosphoenolpyruvate into red cells suspended in media with impermeable solutes was studied at different osmolalities and in the presence of echinocytogenic drugs. The transport rate decreased when cells were incubated in a hyper-osmotic media. The echinocytogenic reagents dipyridamol, salicylate, 2, 4-dinitrophenol and deoxycholate inhibited the transport rate, whereas the spherocytogenic reagents chlorpromazine, procaine, colchicine, vitamin E and Triton X-100 did not.
日本細胞生物学会の論文