Differences in the Transport of Polysomal RNA from Nucleus to Cytoplasm in Rat Liver and Hepatoma AH-130 Cells

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The RNA molecular species synthesized in nuclei were com- pared by the DNA-RNA hybridization technique in normal rat liver and rat ascites hepatoma AH-130 cells. The nuclear RNA (n-RNA) of normal rat liver cells was characterized by a greater amount of AU-rich RNA sedimenting heterogeneously than n-RNA of hepatoma cells. The newly synthesized n-RNA of hepatoma cells contained about 50 % of ribosomal RNA while that of normal rat liver contained 30 %. The hepatoma cells seemed to synthesize the same RNA molecular species as rat liver cells but the RNA molecular species which migrated out of the nucleus into the cytoplasmic polysomal frac- tion were different. Polysomal RNAs in normal rat liver did not contain some RNA molecular species which existed in the hepatoma polysomal fraction, suggesting that the transport of n-RNA to the cytoplasm associated with polysomes was different between hepatoma cells and normal liver cells.
日本細胞生物学会の論文