Trypanosoma cruzi: Phagolysosomal fusion after invasion into non professional phagocytic cells.
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概要
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Parasite-containing endocytic vacuoles are formed during the process of <I>in vitro</I> interiorization of the trypomastigote forms of <I>Trypanosoma cruzi</I> by primary culture of mouse fibroblasts, heart and skeletal muscle cells. Fusion of these vacuoles with host cell lysosomes takes place. The process of T. <I>cruzi</I>-muscle cell interaction was analysed by ultrastructural cytochemistry. Two lysosomal enzymes, acid phosphatase and aryl sulphatase and the fusion of peroxidase-labeled secondary lysosomes with the parasito-phorus vacuoles were studied. These finding indicate that the basic mechanism of interaction of T. <I>cruzi</I> with the so called non phagocytic cells is similar to that whichoccurs with phagocytic cells.
- 日本細胞生物学会の論文
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