Stimulatory effect of amphotericin B methyl ester on the growth of L-M and vero cells.

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• The chemically modified polyene macrolide antibiotic, amphotericin B methyl ester (AME), exhibited a concentration-dependent growth stimulatory effect on established lines of mouse (L-M) and monkey (Vero) cells. Stimulation was indicated by increases in growth rate, and in the enhanced synthesis of DNA and RNA. In contrast, the parental antibiotic amphotericin B and the desoxycholate complex of amphotericin B, Fungizone R, did not elicit a similar proliferative response in L-M or Vero cells. AME was not growth-promoting toward low passage strains of mouse(PMK 6) and monkey cells (GMK 8).

• 公益財団法人 日本感染症医薬品協会の論文

公益財団法人 日本感染症医薬品協会 | 論文

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