Are Autoantibodies against Lewis Antigens Involved in the Pathogenesis of Helicobacter pylori-Induced Peptic Ulcers?
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概要
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We examined whether anti-Lewis x (Lex) and y (Ley) autoantibodies affect the pathogenesis of Helicobacter pylori-induced peptic ulcers. Of 11 patients with peptic ulcers, 10 patients had both anti-Lex and -Ley immunoglobulin G (IgG) antibodies, and 1 patient had only anti-Lex antibody. After successful eradication, we measured the serum titer of anti-Lex and -Ley antibodies. Six patients had a reduction of the titers of anti-Lex and/or -Ley antibodies, whereas no notable changes were detected in 5 patients in the follow-up. This result suggests that anti-Lex and -Ley autoantibodies had no critical role in the development of H. pylori-induced peptic ulcer.
- 微生物学・免疫学学会連合の論文
微生物学・免疫学学会連合 | 論文
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