Protective Immunity Induced by Vaccination with SAG1 Gene-Transfected Cells against Toxoplasma gondii-Infection in Mice
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概要
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To develop a vaccine by augmenting the protective cellular immunity against Toxoplasma gondii (T. gondii)-infection, T. gondii SAG1 gene-transfectants were established by using RMA.S (H-2b), a murine transporter associated with the antigen processing (TAP) molecule-deficient lymphoma line, as a host antigen-presenting cell (APC). Immunization of C57BL/6 mice with the SAG1-transfected RMA.S induced CD8+ cytotoxic T lymphocytes (CTL) specific for not only SAG1-transfected RMA.S but also T. gondii-infected RMA.S, and elicited protective responses to infection with a virulent T. gondii strain, RH.
- 微生物学・免疫学学会連合の論文
微生物学・免疫学学会連合 | 論文
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