Correlation between Increased Susceptibility to Primary Toxoplasma gondii Infection and Depressed Production of Gamma Interferon in Pregnant Mice
スポンサーリンク
概要
- 論文の詳細を見る
To explore a possible mechanism of pregnancy-associated suppression of T cell-mediated immunity to Toxoplasma gondii, acquired resistance and gamma inteferone (IFN-γ) production in pregnant mice were compared with those in virgin mice after infection with the S-273 strain of this protozoan parasite. The 50% lethal dose of this strain was less than 200 tachyzoites for pregnant mice and 2, 800 organisms for virgin controls. Toxoplasma-induced production of both IFN-α and IFN-γ in the bloodstream of pregnant mice was significantly depressed as compared with that in virgin controls. The administration of recombinant murine IFN-γ (rMuIFN-γ) resulted in a significant decrease of mortality and parasitic growth in the organs of pregnant mice infected with a lethal dose of S-273 strain tachyzoites. Thus, the impairment of T cell-mediated immune responses was evident in pregnant mice from the impaired IFN-γ-generating capacity and poor survival rate after primary infection with Toxoplasma. When mice with chronic Toxoplasma infection were injected with specific antigen, the resultant production of IFN-γ was also significantly suppressed during pregnancy. However, there was no direct correlation between the serum levels of IFN-γ and susceptibility to reinfection, since the mortality rate of chronically infected pregnant mice after the challenge with the high virulent RH strain was not significantly higher than that of virgin controls.
- 微生物学・免疫学学会連合の論文
微生物学・免疫学学会連合 | 論文
- The Structural Proteins of Newcastle Disease Virus
- The Pathogenicity of Newcastle Disease Virus Isolated from Migrating and Domestic Ducks and the Susceptibility of the Viral Glycoproteins to Proteolytic Cleavage
- Analysis of Nuclear Accumulation of Influenza Nucleoprotein Antigen Using a Temperature-Sensitive Mutant
- Enhancement of fusion from within by Antiviral Antibody in Cells Infected with Newcastle Disease Virus
- Analysis of Nuclear Accumulation of Influenza Nucleoprotein Antigen in the Presence of p-Fluorophenylalanine