Polyclonal B Cell Activation by Cell Wall Preparations of Gram-Positive Bacteria
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概要
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The effects of polyclonal B cell activation (PBA) of cell walls and their cell wall fractions obtained from several kinds of gram-positive bacteria were studied using the anti-sheep red blood cell (SRBC) or anti-trinitrophenylated (TNP) SRBC plaque forming cell (PFC) responses of cultured spleen cells from Balb/c, athymic nu/nu, their littermates (nu/ +), C3H/He (LPS-responder), C3H/HeJ (LPS-non-responder), (CBA/N × Balb/c) F1 male with an X-linked defect in B cell function and the F 1 female mice. The cell walls of <I>Staphylococcus epidermidis</I> (ATCC 155), <I>Lactobacillus plantarum</I> (ATCC 8014), <I>Micrococcus lysodeikticus</I> (NCTC 2665), <I>Mycobacterium rhodochrous</I> (ATCC 184), <I>Streptomyces gardneri</I> (ATCC 23911) and <I>Nocardia corynebacteriodes</I> (ATCC 14898) had the ability to induce polyclonal B cell responses in the spleen cells of Balb/c, nu/nu, nu/ +, C3H/He and C3H/HeJ mice. The cell wall fractions prepared by enzymatic digestion from the cell walls of <I>S. epidermidis</I>, <I>S. gardneri</I> or <I>N. corynebacteriodes</I> were also capable of inducing polyclonal B cell responses. The responses of spleen cells from (CBA/N ×Balb/c) F 1 male mice to these active preparations, except the cell walls of <I>M. rhodochrous</I>, were much lower than those of the F 1 female mice. These findings indicate that the majority of the cell wall preparations lacks PBA ability for spleen cells with the CBA/N defect, except for the cell walls of <I>M. rhodochrous</I> which possess this ability. The PBA-ability of synthetic peptidoglycan, muramyl dipeptide (<I>N</I>-acetylmuramyl-L-alanyl-D-isoglutamine, MDP), was also examined, and a similar activity was observed in MDP.
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