Nonspecific Stimulation of Antibacterial Resistance by a Synthetic Thymic Factor (FTS) in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of mice with 0.01-1 μg of a synthetic serum thymic factor (FTS) significantly increased their resistance to lethal doses (1-5 × 10<SUP>6</SUP> organisms) of <I>Salmonella typhimurium</I> LT2 (LT2). At least seven injections of FTS were necessary for induction of resistance, since the effects of one to three injections were variable. FTS additively potentiated the protective immunity to LT2 induced by immunization with an avirulent mutant of LT2, irrespective of the structural components of the cell wall lipopolysaccharides of the mutants, which are basically correlated with their immunogenicity and virulence. Activated macrophages may have a direct role in the induction of host resistance, since peritoneal macrophages from FTS-treated DBA/2 mice which are resistant to the doses of LT2 used could by themselves retard bacterial growth <I>in vitro</I>, whereas those from CBA/N mice which are relatively susceptible to LT2 did not inhibit bacterial growth without intervention of FTS-treated syngeneic T cells.
- 微生物学・免疫学学会連合の論文
微生物学・免疫学学会連合 | 論文
- The Structural Proteins of Newcastle Disease Virus
- The Pathogenicity of Newcastle Disease Virus Isolated from Migrating and Domestic Ducks and the Susceptibility of the Viral Glycoproteins to Proteolytic Cleavage
- Analysis of Nuclear Accumulation of Influenza Nucleoprotein Antigen Using a Temperature-Sensitive Mutant
- Enhancement of fusion from within by Antiviral Antibody in Cells Infected with Newcastle Disease Virus
- Analysis of Nuclear Accumulation of Influenza Nucleoprotein Antigen in the Presence of p-Fluorophenylalanine