Dental Caries Induction in Experimental Animls by Clinical Strains of <I>Streptococcus mutans</I> Isolated from Japanese Children
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概要
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Oral implantation and the cariogenic activity of clinical strains of <I>Streptococcus mutans</I> which had been isolated from Japanese children and labeled with streptomycin-resistance were examined in specific pathogen-free Sprague-Dawley rats. All the seven strains tested were easily implanted and persisted during the experimental period. Extensive carious lesions were produced in rats inoculated with clinical strains of S. <I>mutans</I> belonging to serotypes <I>c, d, e</I>, and <I>f</I>, and maintained on caries-inducing diet #2000. Noninfected rats did not develop dental caries when fed diet #2000. Type <I>d S</I>. <I>mutans</I> preferentially induced smooth surface caries in the rats. Strains of other serotypes primarily developed caries of pit and fissure origin. Caries also developed in rats inoculated with reference <I>S. mutans</I> strains BHTR and FAlR (type <I>b</I>) that had been maintained in the laboratories for many years. However, the cariogenicity of the laboratory strains was found to have decreased markedly. All three <I>S. sanguis</I> strains could be implanted, but only one strain induced definite fissure caries. Two <I>S. salivarius</I> strains could not be implanted well in the rats and therefore they were not cariogenic. Four different species of lactobacilli also failed to induce dental caries in rats subjected to similar caries test regimen on diet #2000. S. mutans strain MT6R (type <I>c</I>) also induce caries in golden hamsters and ICR mice, but of variable degrees.
- 微生物学・免疫学学会連合の論文
微生物学・免疫学学会連合 | 論文
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