REACTIVE HYPEREMIA OF HINDLIMB AFTER THE TREATMENT OF IAc, FAc AND DNP

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The reactive hyperemia in dog's hind-limb in the resting state was examined. The methods used were mainly the constant volume perfusion and partly the constant pressure perfusion.<BR>1. The magnitude of the reactive hyperemia was parallel to the length of occlusion time, while the maximal dilatation of artery was obtained after one minute occlusion. The duration of the reactive hyperemia was almost the same when the perfusion volume was above a certain level (26 ml/min) in the constant volume perfusion, and the perfusion pressure above a certain level (50 mmHg) in the constant pressure perfusion.<BR>2. The inhibition of metabolism by use of IAc or FAc caused the disappearance of the reactive hyperemia and further the vasoconstriction after the release of occlusion. The acceleration of metabolism by uncoupling action of DNP caused the augmentation of the reactive hyperemia. The vascular responses of acetylcholine, bradykinin and adenosine were not changed by FAc treatment, while they were diminished, or even converted to vasoconstriction, by IAc treatment.<BR>3. The different mediator substance will probably be released from the poisoned tissue by use of FAc and IAc when the metabolism is inhibited by these substances.
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