THE ROLE OF LYSOSOMAL ENZYMES IN THE PATHOGENESIS OF SHOCK:NATURE OF CIRCULATORY DEPRESSION INDUCED BY INTRAVENOUS INFUSION OF LYSOSOMAL ENZYMES

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Many investigators suggested the role of lysosomal hydrolases released into systemic circulation as a causative factor of cardiovascular depression during shock. The present study was undertaken to clarify the nature of circulatory derangement induced by intravenous administration of lysosomal extracts. The liver of mongrel dogs was excised for the separation of contents of lysosomal pellets with homogenization and centrifugation.<BR>Cardiovascular function including myocardial contractility and peripheral vascular performance was assessed during and some time after the infusion of lysosomal extracts. Profound hypotension and decrease in cardiac output were observed. However, myocardial contractility was not impaired on the measures such as dp/dt/p and Vmax obtained by left ventricular catheterization. Peripheral vascular resistance was observed to be significantly lowered in the constantly perfused hind limb circuits of dogs.<BR>These results indicate that lysosomal hydrolases released into systemic circulation may cause vasodilation and pooling of blood in peripheral vascular bed and may not deteriorate myocardial contractility.
北関東医学会の論文